Symptoms of Hyperparathyroidism
Symptoms of primary hyperparathyroidism include osteoporosis (thin bones), bone pain, kidney stones, and abdominal discomfort. Osteoporosis is caused by excessive action of osteoclasts, which are cells that break down bone tissue. This in turn may lead to bone pain and even fractures. Kidney stones are also caused by excessive calcium in the kidney and urine.
In addition, PTH affects the mind and mental health. An excess of PTH can be associated with feelings of anxiety and fatigue. Other symptoms include sleep difficulty, headaches, difficulty concentrating, and depression.
Elevated PTH may also have a direct toxic effect on the function of the heart muscle. Studies have shown that after a successful parathyroid operation , many (but not all) of these heart problems can significantly, if not completely, improve.
In the case of primary hyperparathyroidism, drugs will not counteract the effects of elevated PTH.